Acute Effects of Ecstasy on Memory Are more Extensive than Chronic Effects

نویسندگان

  • Ali Nikkhah Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
  • Fatemeh Mirzaei Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  • Maryam Sohrabi Anatomy Department, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  • Mehdi Medizadeh Cellular & Molecular Research Center, Faculty of Advanced Technology in Medicne, Department of Anatomical Sciences, Iran University of Medical Sciences, Tehran, Iran
  • Mohamad Bakhtiar Hesam Shariati Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, Iran
  • Sara Soleimani Asl Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, Iran
  • Siamak Shahidi Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
چکیده مقاله:

Introduction: Exposure to 3, 4- methylenedioxymethamphetamine (MDMA) could lead to serotonergic system toxicity in the brain. This system is responsible for learning and memory functions. Studies show that MDMA causes memory impairment dose-dependently and acutely. The present study was designed to evaluate the chronic and acute effects of MDMD on spatial memory and acquisition of passive avoidance. Methods: Adult male Wistar rats (200-250 g) were given single or multiple injections of MDMA (10 mg/kg, IP). Using passive avoidance and Morris Water Maze (MWM) tasks, learning and spatial memory functions were assessed. The data were analyzed by SPSS 16 software and one- way analysis of variance (ANOVA) test. Results: Our results showed that there were significant differences in latency to enter the dark compartment (STL) between sham and MDMA- treated groups. Acute group significantly showed more STL in comparison with chronic group. Furthermore, MDMA groups spent more time in dark compartment (TDS) than the sham group. Administration of single dose of MDMA significantly caused an increase in TDS compared with the chronic group. In the MWM, MDMA treatment significantly increased the traveled distance and escaped latency compared to the sham group. Like to passive avoidance task, percentage of time spent in the target quadrant in MDMA- treated animals impaired in MWM compared with sham group. Discussion: These data suggest that MDMA treatment impairs learning and memory functions that are more extensive in acute- treated rats.

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acute effects of ecstasy on memory are more extensive than chronic effects

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عنوان ژورنال

دوره 5  شماره 3

صفحات  225- 230

تاریخ انتشار 2014-07

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